Blood Group Testing

Frontiers in Medicine

article

Hong-Yang Li¹  Kai Guo² 

[1] Department of Blood Transfusion, China-Japan Union Hospital of Jilin University;Department of Transfusion Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health;National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology;Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences

关键词: red blood cell;    blood group typing;    blood group testing;    blood group antigen;    ABO blood group system;    RH blood group system;   

DOI  :  10.3389/fmed.2022.827619

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Red blood cell (RBC) transfusion is one of the most frequently performed clinical procedures and therapies to improve tissue oxygen delivery in hospitalized patients worldwide. Generally, the cross-match is the mandatory test in place to meet the clinical needs of RBC transfusion by examining donor-recipient compatibility with antigens and antibodies of blood groups. Blood groups are usually an individual's combination of antigens on the surface of RBCs, typically of the ABO blood group system and the RH blood group system. Accurate and reliable blood group typing is critical before blood transfusion. Serological testing is the routine method for blood group typing based on hemagglutination reactions with RBC antigens against specific antibodies. Nevertheless, emerging technologies for blood group testing may be alternative and supplemental approaches when serological methods cannot determine blood groups. Moreover, some new technologies, such as the evolving applications of blood group genotyping, can precisely identify variant antigens for clinical significance. Therefore, this review mainly presents a clinical overview and perspective of emerging technologies in blood group testing based on the literature. Collectively, this may highlight the most promising strategies and promote blood group typing development to ensure blood transfusion safety.

【 授权许可】

CC BY