Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma

Frontiers in Medicine

article

Revati Sharma¹  George Kannourakis¹  Prashanth Prithviraj¹  Nuzhat Ahmed¹ 

[1] Fiona Elsey Cancer Research Institute, Ballarat Central Technology Central Park, Ballarat Central;School of Science, Psychology and Sport, Federation University;Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University;Department of Obstetrics and Gynaecology, University of Melbourne

关键词: renal cell carcinoma;    gut microbiome;    artificial intelligence;    precision medicine;    nanomedicine;   

DOI  :  10.3389/fmed.2022.766869

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Renal cell cancer (RCC) is a heterogeneous tumor that shows both intra- and inter-heterogeneity. Heterogeneity is displayed not only in different patients but also among RCC cells in the same tumor, which makes treatment difficult because of varying degrees of responses generated in RCC heterogeneous tumor cells even with targeted treatment. In that context, precision medicine (PM), in terms of individualized treatment catered for a specific patient or groups of patients, can shift the paradigm of treatment in the clinical management of RCC. Recent progress in the biochemical, molecular, and histological characteristics of RCC has thrown light on many deregulated pathways involved in the pathogenesis of RCC. As PM-based therapies are rapidly evolving and few are already in current clinical practice in oncology, one can expect that PM will expand its way toward the robust treatment of patients with RCC. This article provides a comprehensive background on recent strategies and breakthroughs of PM in oncology and provides an overview of the potential applicability of PM in RCC. The article also highlights the drawbacks of PM and provides a holistic approach that goes beyond the involvement of clinicians and encompasses appropriate legislative and administrative care imparted by the healthcare system and insurance providers. It is anticipated that combined efforts from all sectors involved will make PM accessible to RCC and other patients with cancer, making a tremendous positive leap on individualized treatment strategies. This will subsequently enhance the quality of life of patients.

【 授权许可】

CC BY