Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Frontiers in Medicine

article

Dominic Stanculescu¹  Jonas Bergquist² 

[1] Independent Researcher;Division of Analytical Chemistry and Neurochemistry, Department of Chemistry – Biomedical Center, Uppsala University;The Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ,(ME/CFS) Collaborative Research Centre at Uppsala University

关键词: post-viral fatigue;    hypoperfusion;    endotheliopathy;    gut permeability;    endotoxemia;    pituitary;    non-thyroidal illness syndrome;    myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS);   

DOI  :  10.3389/fmed.2022.818728

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

We propose an initial explanation for how myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) could originate and perpetuate by drawing on findings from critical illness research. Specifically, we combine emerging findings regarding (a) hypoperfusion and endotheliopathy, and (b) intestinal injury in these illnesses with our previously published hypothesis about the role of (c) pituitary suppression, and (d) low thyroid hormone function associated with redox imbalance in ME/CFS. Moreover, we describe interlinkages between these pathophysiological mechanisms as well as “vicious cycles” involving cytokines and inflammation that may contribute to explain the chronic nature of these illnesses. This paper summarizes and expands on our previous publications about the relevance of findings from critical illness for ME/CFS. New knowledge on diagnostics, prognostics and treatment strategies could be gained through active collaboration between critical illness and ME/CFS researchers, which could lead to improved outcomes for both conditions.

【 授权许可】

CC BY