Neurotrophic Keratopathy in Systemic Diseases: A Case Series on Patients Treated With rh-NGF

Frontiers in Medicine

article

Alessandro Meduri¹  Giovanni William Oliverio¹  Antonio Valastro¹  Claudia Azzaro¹  Umberto Camellin¹  Francesco Franchina¹  Leandro Inferrera²  Anna Roszkowska¹  Pasquale Aragona¹ 

[1] Department of Biomedical Sciences, Ophthalmology Clinic, University of Messina;Department of Medical, Surgical Sciences and Health, Eye Clinic, University of Trieste;Department of Ophthalmology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University

关键词: neurotrophic keratopathy;    rh-NGF;    neurotrophic keratitis;    Cenegermin;    nerve growing factor;   

DOI  :  10.3389/fmed.2022.920688

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose To evaluate the prevalence, clinical ocular presentation and corneal healing in moderate and severe neurotrophic keratopathy (NK) caused by systemic diseases and treated with rh-NGF. Setting Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Ophthalmology Clinic, University of Messina, Italy. Design Retrospective observational study of case series. Materials and Methods In this retrospective observational study 11 patients (five female and six males) aged from 24 to 88 years (55.4 ± 21.3 years) with moderate and severe NK caused by systemic diseases were enrolled. The VAS questionnaire was dispensed. The ocular examination comprised slit lamp evaluation, ocular surface assessment with Keratograph 5M (Oculus, Germany), corneal sensitivity with Cochet-Bonnet esthesiometer (Lunneaux, France) and corneal thickness measurement with AC-OCT (DRI, Triton, Topcon, Japan). The underlying systemic causes of NK were determined. Results The main cause of NK was post-neuroma surgery (36%), followed by diabetes (18%). The remaining causes were rheumatoid arthritis (9%), post-traumatic (9%), post-surgery (9%), atopia (9%), Graves' disease (9%). Seven eyes presented severe grade of NK with corneal ulcer and in four a moderate grade was registered. The rh-NGF (Cenegermin) was administered with a standard protocol one drop six times daily for 8 weeks. The complete healing of all corneal defects was registered at the end of the treatment. Conclusions The post-neuroma surgery was the most common cause of NK and severe grade was clinically more represented. The rh-NGF proved effective to promote corneal recovery with all defects healed after the treatment.

【 授权许可】

CC BY