The Prognostic Prediction Value of Positive Lymph Nodes Numbers for the Hypopharyngeal Squamous Cell Carcinoma

Frontiers in Medicine

article

Wendu Pang¹  Yaxin Luo²  Junhong Li¹  Danni Cheng¹  Yufang Rao¹  Minzi Mao¹  Ke Qiu¹  Yijun Dong¹  Jun Liu¹  Jian Zou¹  Haiyang Wang¹  Fei Chen¹ 

[1] Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University;Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University

关键词: hypopharyngeal squamous cell carcinoma;    positive lymph nodes number;    prognosis;    prediction models;    survival predictive values;   

DOI  :  10.3389/fmed.2022.898483

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background The current American Joint Committee on Cancer (AJCC) system only considered the importance of the size and laterality of lymph nodes while not the positive lymph node number (PLNN) for hypopharyngeal squamous cell carcinoma (HPSCC). Methods A total of 973 patients with HPSCC from the Surveillance, Epidemiology, and End Results database (2004–2015) were identified. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic effects. We applied six Cox regression models to compare the survival prognostic values of PLNN and AJCC systems. Results Positive lymph node number showed a significant association with overall survival (OS) and cancer-specific survival (CSS) ( P < 0.001) in univariate and multivariable analyses. The increased PLNN of HPSCC gave rise to poor OS and CSS. The survival model incorporating a composite of PLNN and TNM classification (C-index for OS:0.682, C-index for CSS:0.702) performed better than other models. Conclusions A positive lymph node number could serve as a survival predictor for patients with HPSCC and a complement to enhance the prognostic assessment effects of TNM cancer staging systems.

【 授权许可】

CC BY