Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease

Frontiers in Medicine

article

Xinwei Deng¹  Bixia Gao¹  Fang Wang¹  Ming-hui Zhao¹  Jinwei Wang¹  Luxia Zhang¹ 

[1] Renal Division, Department of Medicine, Peking University First Hospital;Institute of Nephrology, Peking University;Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences;Key Laboratory of Renal Disease, Ministry of Health of China;Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China;Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University;National Institute of Health Data Science, Peking University

关键词: chronic kidney disease (CKD);    rapid CKD progression;    kidney outcomes;    red blood cell distribution width;    estimated glomerular filtration rate (eGFR) slope;   

DOI  :  10.3389/fmed.2022.877220

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Chronic kidney disease (CKD) is a global public health issue. Red blood cell distribution width (RDW) is a recently recognized potential inflammatory marker, which mirrors the variability in erythrocyte volume. Studies indicate that elevated RDW is associated with increased risk of mortality in CKD patients, while evidence regarding the impact of RDW on kidney outcome is limited. Methods Altogether 523 patients with CKD stage 1–4 from a single center were enrolled. We identified the cutoff point for RDW level using maximally selected log-rank statistics. The time-averaged estimated glomerular filtration rate (eGFR) slope was determined using linear mixed effects models. Rapid CKD progression was defined by an eGFR decline >5 ml/min/1.73 m 2 /year. The composite endpoints were defined as doubling of serum creatinine, a 30% decline in initial eGFR or incidence of eGFR 14.5% and ≤14.5%, respectively, P for between-group difference <0.05}. So was the risk of rapid renal function loss (odds ratio = 6.79, 95% CI: 3.08–14.97) and composite kidney outcomes (hazards ratio = 1.51, 95% CI: 1.02–2.23). The significant association remained consistent in the sensitivity analysis. Conclusion Increased RDW value is independently associated with accelerated CKD deterioration. Findings of this study suggest RDW be a potential indicator for risk of CKD progression.

【 授权许可】

CC BY