期刊论文详细信息
Frontiers in Medicine
The Effect of Elevated Alanine Transaminase on Non-invasive Prenatal Screening Failures
article
Ping Chen1  Longwei Qiao2  Sheng Zhang3  Jieyu Jin3  Jun Cao3  Yuqiong Zhang4  Haoyu Tang2  Zheng Yu2  Jingye Shi2  JingPing Yin3  Yuting Liang3  Xiao Wu1 
[1] Department of Obstetrics, School of Gusu, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University;Center for Reproduction and Genetics, School of Gusu, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University;Center for Clinical Laboratory, The First Affiliated Hospital of Soochow University;Department of Medical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University
关键词: non-invasive prenatal screening;    fetal fraction;    cell-free DNA;    ALT;    multivariable linear regression models;   
DOI  :  10.3389/fmed.2022.875588
学科分类:社会科学、人文和艺术(综合)
来源: Frontiers
PDF
【 摘 要 】

Objective To determine the effects of alanine transaminase (ALT) levels on the screening failure rates or “no calls” due to low fetal fraction (FF) to obtain a result in non-invasive prenatal screening (NIPS). Methods NIPS by sequencing and liver enzyme measurements were performed in 7,910 pregnancies at 12–26 weeks of gestation. Univariate and multivariable regression models were used to evaluate the significant predictors of screening failure rates among maternal characteristics and relevant laboratory parameters. Results Of the 7,910 pregnancies that met the inclusion criteria, 134 (1.69%) had “no calls.” Multiple logistic regression analysis demonstrated that increased body mass index, ALT, prealbumin, albumin levels, and in vitro fertilization (IVF) conception rates were independently associated with screening failures. The test failure rate was higher (4.34 vs. 1.41%; P 40 U/L. In particular, IVF pregnancies with an ALT level of >40 U/L had a higher test failure rate (9.52%). Compared with that for an ALT level of ≤10 U/L, the adjusted odds ratio of “no calls” for ALT levels of 10–20, 21–40, and >40 U/L was 1.204 [95% confidence interval (CI), 0.709–2.045], 1.529 (95% CI, 0.865–2.702), and 2.764 (95% CI, 1.500–5.093) ( P trend < 0.001), respectively. Conclusions Increased ALT and IVF conceptions were associated with a higher screening failure rates in NIPS. Therefore, a feasible strategy to adjust these factors to reduce the probability of “no calls” due to low FF would be of great clinical significance.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202301300009890ZK.pdf 2361KB PDF download
  文献评价指标  
  下载次数:1次 浏览次数:0次