2% Ganciclovir Eye Drops Control Posner-Schlossman Syndrome Relapses With/Without Cytomegalovirus Intraocular Reactivation

Frontiers in Medicine

article

Qilian Sheng¹  Ruyi Zhai¹  Xintong Fan¹  Xiangmei Kong¹ 

[1] Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University;National Health Commission Key Laboratory of Myopia ,(Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences;Shanghai Key Laboratory of Visual Impairment and Restoration

关键词: topical ganciclovir treatment;    cytomegalovirus infections;    Posner-Schlossman Syndrome;    ophthalmic solutions;    antiviral therapy;   

DOI  :  10.3389/fmed.2022.848820

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background To observe and compare the efficacy of 2% ganciclovir eye drops in the treatment of Posner-Schlossman Syndrome relapses with/without cytomegalovirus intraocular reactivation. Methods A prospective cohort study enrolling 101 patients diagnosed unilateral Posner-Schlossman Syndrome in Eye & ENT hospital, Fudan University, Shanghai, China. Thorough ophthalmic examinations were given. Aqueous humor sample was collected from the attacked eye of each patient and all pathogen immunoglobulins tests were performed. All patients were treated with appropriate corticosteroids and intraocular pressure-lowering drugs. 2% ganciclovir eye drops were given to patients whose cytomegalovirus antibody aqueous humor/serum correction ratio >0. Patients were followed up for 2 months. Ocular manifestations and cumulative drug dose were recorded. Results A cytomegalovirus ratio >0.40 was considered cytomegalovirus reactivation. The reactivation group ( N = 46) had significantly higher percent of iris depigmentation (78.26%, P 0.05). The median cumulative 2% ganciclovir estimated for inflammation control were 252.00 ± 50.71 and 224.00 ± 32.45 drops for the reactivation and latent group. The residual rate of uncontrolled cases was 0.19 ± 0.15 and 0.00, respectively ( P < 0.05). Conclusions A treatment course of 8–9 weeks' 2% ganciclovir is recommended to relapses both with and without cytomegalovirus intraocular reactivation. Preventive ganciclovir application may benefit patients with historical cytomegalovirus infections.

【 授权许可】

CC BY