Prediction of MYCN Amplification, 1p and 11q Aberrations in Pediatric Neuroblastoma via Pre-therapy 18F-FDG PET/CT Radiomics

Frontiers in Medicine

article

Luodan Qian¹  Shen Yang²  Shuxin Zhang¹  Hong Qin²  Wei Wang¹  Ying Kan¹  Lei Liu³  Jixia Li⁴  Hui Zhang⁶  Jigang Yang¹ 

[1] Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University;Department of Surgical Oncology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University;Sinounion Medical Technology ,(Beijing) Co., Ltd.;Department of Molecular Medicine and Pathology, School of Medical Science, The University of Auckland;Department of Laboratory Medicine of Medical School, Foshan University;Department of Biomedical Engineering, School of Medicine, Tsinghua University

关键词: 18F-FDG PET/CT;    radiomics;    neuroblastoma;    MYCN amplification;    1p aberration;    11q aberration;   

DOI  :  10.3389/fmed.2022.840777

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose This study aimed to assess the predictive ability of 18F-FDG PET/CT radiomic features for MYCN, 1p and 11q abnormalities in NB. Method One hundred and twenty-two pediatric patients (median age 3. 2 years, range, 0.2–9.8 years) with NB were retrospectively enrolled. Significant features by multivariable logistic regression were retained to establish a clinical model (C_model), which included clinical characteristics. 18F-FDG PET/CT radiomic features were extracted by Computational Environment for Radiological Research. The least absolute shrinkage and selection operator (LASSO) regression was used to select radiomic features and build models (R-model). The predictive performance of models constructed by clinical characteristic (C_model), radiomic signature (R_model), and their combinations (CR_model) were compared using receiver operating curves (ROCs). Nomograms based on the radiomic score (rad-score) and clinical parameters were developed. Results The patients were classified into a training set ( n = 86) and a test set ( n = 36). Accordingly, 6, 8, and 7 radiomic features were selected to establish R_models for predicting MYCN, 1p and 11q status. The R_models showed a strong power for identifying these aberrations, with area under ROC curves (AUCs) of 0.96, 0.89, and 0.89 in the training set and 0.92, 0.85, and 0.84 in the test set. When combining clinical characteristics and radiomic signature, the AUCs increased to 0.98, 0.91, and 0.93 in the training set and 0.96, 0.88, and 0.89 in the test set. The CR_models had the greatest performance for MYCN, 1p and 11q predictions ( P < 0.05). Conclusions The pre-therapy 18F-FDG PET/CT radiomics is able to predict MYCN amplification and 1p and 11 aberrations in pediatric NB, thus aiding tumor stage, risk stratification and disease management in the clinical practice.

【 授权许可】

CC BY