Clinical Factors and Perinatal Outcomes Associated With Short Latency Period in Twin Pregnancies With Preterm Premature Rupture of Membranes Before 34 Weeks: A Retrospective Study

Frontiers in Medicine

article

Shuwei Zhou¹  Lingwei Mei¹  Wei Zhou¹  Yajun Yang¹  Xiaoyan Zhang¹  Xiaoling Mu²  Quan Quan²  Lan Wang¹ 

[1] Department of Obstetrics, Chongqing Health Center for Women and Children;Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University

关键词: twin pregnancies;    preterm premature rupture of membranes;    latency period;    clinical factors;    perinatal outcomes;   

DOI  :  10.3389/fmed.2022.839240

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background There is a lack of literature on short latency period (SLP) in twin pregnancies with preterm premature rupture of membranes (PPROM). Thus, the aim of this study was to identify the clinical factors and perinatal outcomes associated with SLP in twin pregnancies with PPROM and to establish a predictive model to identify SLP. Methods Twin pregnancies with PPROM between 24 0/7 and 33 6/7 weeks were included and a retrospective analysis was performed. Patients were divided into two groups based on the latency period after PPROM: Group 1 ≤24 h (defined as SLP) and Group 2 >24 h (defined as long latency period, LLP), the clinical factors and perinatal outcomes were compared between the two groups. Binary logistic regression and receiver operating characteristic curve analyses were used to identify the independent clinical factors associated with latency period after PPROM and assess the predictive accuracy for SLP. Results 98 and 92 pregnant women had short and long latency period, respectively. Prolonged latency significantly increased the occurrence of chorioamnionitis. Neonatal outcomes were not affected by latency duration after PPROM. Binary regression analysis revealed that higher gestational age (GA) at PPROM ( P = 0.038), presence of uterine contractions ( P 4 ( P = 0.030), serum procalcitonin levels ≥0.05 ng/mL upon admission, and absence of use of tocolytic agents ( P 24 h was associated with chorioamnionitis, but adverse neonatal outcomes were not observed.

【 授权许可】

CC BY