Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children

Frontiers in Medicine

article

Xiang Lu¹  Hao Wang³  Jingqi Zhang²  Kexin Jin⁴  Ling Ma¹  Yan Wang²  Shixing Yang²  Xiaochun Wang²  Quan Shen²  Tianji Zhou²  Hui Xu¹  Wen Zhang² 

[1] Department of Dermatology, The Affiliated Hospital of Jiangsu University;Department of Microbiology, School of Medicine, Jiangsu University;Department of Clinical Laboratory, The Affiliated Huai'an Hospital of Xuzhou Medical University;School of Mathematical Sciences, Soochow University

关键词: atopic dermatitis;    virome;    gut;    metagenomics;    diversity;   

DOI  :  10.3389/fmed.2022.835467

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic diseases. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects nearly 20% of children. To date, metagenomics research on AD has mainly focused on the skin and gut microbiome. However, here we assessed the composition of the virome in the gut of AD patients and healthy controls for the first time. This study has obtained possible dominant viruses at different viral classification levels. In terms of diversity, the alpha diversity of the patients group was significantly lower than that of the healthy controls group, and the beta diversity of the two groups was significantly different from phylum to family level. These findings provide a new perspective for us to better understand the effect of the gut microecological environment on AD.

【 授权许可】

CC BY