Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects

Frontiers in Medicine

article

Riccardo Vinciguerra¹  Robert Herber²  Yan Wang³  Fengju Zhang⁵  Xingtao Zhou⁶  Ji Bai⁷  Keming Yu⁸  Shihao Chen⁹  Xuejun Fang^1,10  Frederik Raiskup²  Paolo Vinciguerra^1,11 

[1] Humanitas San Pio X Hospital;Department of Ophthalmology, University Hospital Carl Gustav Carus;Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital;Clinical College of Ophthalmology, Tianjin Medical University;Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Lab, Capital Medical University;EYE & ENT Hospital of Fudan University;BAI JI Ophthalmology;Zhongshan Ophthalmic Center, Sun Yat-Sen University;Eye Hospital, Wenzhou Medical University;Shenyang Aier Eye Hospital;Department of Biomedical Sciences, Humanitas University;IRCCS Humanitas Research Hospital

关键词: biomechanics;    cornea;    keratoconus;    CBI;    IOP (intraocular pressure);   

DOI  :  10.3389/fmed.2022.834663

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose The aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs). Methods Two thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm. The DCRs assessed were Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R), deformation amplitude ratio (DAratio), stiffness parameter at applanation 1 (SPA1), ARTh (Ambrósio's Relational Thickness to the horizontal profile), and the novel Stress Strain Index (SSI). Results After age-, CCT-, and IOP- matching, 503 Chinese were assigned to 452 Caucasians participants. Statistical analysis showed a statistical significant difference between Chinese and Caucasian Healthy subjects in the values of SPA1 ( p = 0.008), Arth ( p = 0.008), and SSI ( p 0.05). Conclusion We found significant differences in the values of the DCRs provided by the Corvis ST between Chinese and Caucasian healthy subjects.

【 授权许可】

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