Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation

Frontiers in Medicine

article

Qianqian Wang¹  Min Jiang¹  Chengfeng Zhang¹  Hamm-Ming Sheu²  Chrang-Shi Lin³  Leihong Xiang¹  Juemin Zhao¹  Yanjun Dan¹  Ziqi Liu¹ 

[1] Department of Dermatology, Huashan Hospital, Fudan University;Kao Chao-Hsing Dermatologic Clinic;Department of Dermatology and Family Medicine, National Yang-Ming Chiao-Tung University;Dr. Lin Skin Clinic

关键词: post-inflammatory hyperpigmentation (PIH);    SM (solamargine);    p38;    MAPK;    Nrf2;    HO-1;    inflammation;    melanogenesis;   

DOI  :  10.3389/fmed.2022.812653

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Post-inflammatory hyperpigmentation (PIH) is a common acquired pigmentary disorder occurring after skin inflammation or injury. Ultraviolet B irradiation could exaggerate PIH clinically due to its effect on promoting cutaneous inflammation and melanogenesis in keratinocytes and melanocytes, respectively. Solamargine (SM), a steroidal alkaloid glycoside extracted from Solanum undatum , significantly inhibits Ultraviolet B (UVB)-induced pro-inflammatory cytokines IL-1α, IL-1β, IL-8, and IFN-γ, as well as paracrine melanogenic factors ET-1, α-MSH, and bFGF in human keratinocytes. Additionally, SM significantly attenuated UVB-induced melanin synthesis in human epidermal melanocytes through down-regulation of tyrosinase activity and expression of MITF, TRP-1, TRP-2, and tyrosinase. SM exerted an anti-inflammatory effect in UVB-irradiated keratinocytes through the p38 MAPK/Nrf2/HO-1 signaling pathway. With its anti-inflammatory and whitening effect, SM may improve PIH through paracrine regulations of keratinocytes and direct action on melanocytes, making it a promising agent for PIH.

【 授权许可】

CC BY