Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease

Frontiers in Medicine

article

Shuo-Ming Ou¹  Kuo-Hua Lee¹  Ming-Tsun Tsai¹  Wei-Cheng Tseng¹  Yuan-Chia Chu⁷  Der-Cherng Tarng¹ 

[1] Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital;School of Medicine, National Yang-Ming University;School of Medicine, National Yang Ming Chiao Tung University;Institute of Clinical Medicine, National Yang-Ming University;Institute of Clinical Medicine, National Yang Ming Chiao Tung University;Center for Intelligent Drug Systems and Smart Bio-Devices ,(IDS2B), National Yang Ming Chiao Tung University, Hsinchu;Information Management Office, Taipei Veterans General Hospital;Big Data Center, Taipei Veterans General Hospital;Department of Information Management, National Taipei University of Nursing and Health Sciences;Department and Institute of Physiology, National Yang-Ming University;Department and Institute of Physiology, National Yang Ming Chiao Tung University

关键词: sepsis;    chronic kidney disease;    AKI (acute kidney injury);    renal function decline;    end-stage renal disease;   

DOI  :  10.3389/fmed.2022.809292

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Sepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown. Methods From 2011 to 2018, we included 1,12,628 patients with chronic kidney disease (CKD) aged ≥ 20 years. The patients with CKD were further divided into 11,661 sepsis group and 1,00,967 non-sepsis group. The following outcome of interest was included: all-cause mortality, readmission for acute kidney injury, estimated glomerular filtration rate decline ≥50% or doubling of serum creatinine, and end-stage renal disease. Results After propensity score matching, the sepsis group was at higher risks of all-cause mortality [hazard ratio (HR) 1.39, 95% CI, 1.31–1.47], readmission for acute kidney injury (HR 1.67, 95% CI 1.58–1.76), eGFR decline ≥ 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78–4.01), and end-stage renal disease (HR 1.43, 95% CI 1.34–1.53) than non-sepsis group. Conclusions Our study found that patients with CKD discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events.

【 授权许可】

CC BY