Inflammation-Related Genes Serve as Prognostic Biomarkers and Involve in Immunosuppressive Microenvironment to Promote Gastric Cancer Progression

Frontiers in Medicine

article

Yuanfeng Wei¹  Limin Gao²  Xi Yang¹  Xiaoyu Xiang²  Cheng Yi¹ 

[1] Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University;Department of Pathology, West China Hospital, Sichuan University

关键词: tumor microenvironment;    immunosuppressive;    gastric cancer;    prognostic biomarkers;    inflammation;   

DOI  :  10.3389/fmed.2022.801647

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Gastric cancer (GC) is a typical inflammatory-related malignant tumor which is closely related to helicobacter pylori infection. Tumor inflammatory microenvironment plays a crucial role in tumor progression and affect the clinical benefit from immunotherapy. In recent years, immunotherapy for gastric cancer has achieved promising outcomes, but not all patients can benefit from immunotherapy due to tumor heterogeneity. In our study, we identified 29 differentially expressed and prognostic inflammation-related genes in GC and normal samples. Based on those genes, we constructed a prognostic model using a least absolute shrinkage and selection operator (LASSO) algorithm, which categorized patients with GC into two groups. The high-risk group have the characteristics of “cold tumor” and have a poorer prognosis. In contrast, low-risk group was “hot tumor” and had better prognosis. Targeting inflammatory-related genes and remodeling tumor microenvironment to turn “cold tumor” into “hot tumor” may be a promising solution to improve the efficacy of immunotherapy for patients with GC.

【 授权许可】

CC BY