Case Report: Acute Pancreatitis Associated With Tacrolimus in Kidney Transplantation and a Review of the Literature

Frontiers in Medicine

article

Yixuan Ding¹  Chang Qu¹  Huan He³  Feng Cao¹  Tongwen Ou³  Fei Li¹ 

[1] Department of General Surgery, Xuanwu Hospital, Capital Medical University;Clinical Center for Acute Pancreatitis, Capital Medical University;Department of Urology, Xuanwu Hospital, Capital Medical University

关键词: drug-induced pancreatitis;    tacrolimus;    kidney transplantation;    acute pancreatitis;    abdominal pain;   

DOI  :  10.3389/fmed.2022.843870

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Drug-induced pancreatitis is a rare cause of acute pancreatitis. Tacrolimus has been used as an immunosuppressant agent in patients after organ transplantation. However, only a few case reports of tacrolimus-induced acute pancreatitis in kidney transplantation have been reported. The purpose of this case report is to alert clinicians that tacrolimus-induced acute pancreatitis may occur during tacrolimus therapy in kidney transplant patients. Case Presentation We present the case of a 38-year-old woman who underwent kidney transplantation and received immunosuppressive therapy with tacrolimus; on day 20 post-transplantation, she presented with acute abdominal pain in the middle and left areas of the abdomen accompanied by diarrhea, nausea, and vomiting. We excluded gallstone disease, alcohol, hypertriglyceridemia, and other possible causes, and speculated that tacrolimus was the probable cause of pancreatitis because of the extremely high blood concentration of tacrolimus. After tacrolimus was changed to cyclosporine, her symptoms were gradually improved, and she was discharged home without relapse. Conclusion Tacrolimus is a rare cause of pancreatitis after kidney transplantation. It is important to note that tacrolimus-induced acute pancreatitis may occur during tacrolimus therapy in kidney transplantation patients.

【 授权许可】

CC BY