Case Report: Myocarditis After COVID-19 Vaccination – Case Series and Literature Review

Frontiers in Medicine

article

Samuel Nunn¹  Johannes Kersten¹  Marijana Tadic¹  Alexander Wolf¹  Birgid Gonska¹  Elina Hüll¹  Hanna Dietenberger²  Wolfgang Rottbauer¹  Dominik Buckert¹ 

[1] Department for Internal Medicine II, University of Ulm;Department of Pathology, University of Ulm

关键词: SARS-CoV-2;    myocarditis;    mRNA vaccines;    echocardiography;    cardiovascular magnetic resonance (CMR);    endomyocardial biopsy (EMB);    speckle tracking;   

DOI  :  10.3389/fmed.2022.836620

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background The ongoing COVID-19 pandemic demands a series of measures and, above all, the vaccination of a substantial proportion of the population. Acute myocarditis is a rare complication of the widely used mRNA-based vaccines. Case Presentation We present a case series of four patients (three men and one woman, 16 to 47 years old) with acute pericarditis/myocarditis 3 to 17 days after mRNA vaccination. They presented with chest pain, fever, and flu-like symptoms. Diagnosis was made based on the synopsis of clinical presentation, elevated levels of troponin T and NT-proBNP, impaired systolic function on echocardiography, and findings in non-invasive tissue characterization by cardiovascular magnetic resonance imaging. Two patients also underwent endomyocardial biopsies. As none of the patients showed signs of cardiogenic shock, they were discharged from ward care only a few days after their initial presentations. Conclusions Our data are consistent with other case reports of myocarditis early after mRNA vaccination and demonstrate the need for multimodal diagnostics. In view of its rarity and mild course, the risk–benefit ratio of vaccination remains positive compared to potential SARS-CoV-2 infection.

【 授权许可】

CC BY