COVID-19-Triggered Acute Exacerbation of IPF, an Underdiagnosed Clinical Entity With Two-Peaked Respiratory Failure: A Case Report and Literature Review

Frontiers in Medicine

article

Yosuke Goto¹  Koji Sakamoto¹  Jun Fukihara¹  Atsushi Suzuki¹  Norihito Omote¹  Akira Ando¹  Yuichiro Shindo¹  Naozumi Hashimoto¹ 

[1] Department of Respiratory Medicine, Nagoya University Graduate School of Medicine

关键词: COVID-19;    acute exacerbation;    idiopathic pulmonary fibrosis;    high resolution CT scan;    viral infection;   

DOI  :  10.3389/fmed.2022.815924

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Because severe coronavirus disease 2019 (COVID-19) affects the respiratory system and develops into respiratory failure, patients with pre-existing chronic lung disorders, such as idiopathic pulmonary fibrosis (IPF), are thought to be at high risk of death. Patients with IPF often suffer from a lethal complication, acute exacerbation (AE), a significant part of which is assumed to be triggered by respiratory viral infection. However, whether mild to moderate COVID-19 can trigger AE in patients with IPF remains unknown. This is the case report of a 60-year-old man with a 4-year history of IPF who successfully recovered from moderate COVID-19 but subsequently developed more severe respiratory failure, which was considered to be a COVID-19-triggered acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). It is important to be aware of the risk of AE-IPF after COVID-19 and to properly manage this deadly complication of IPF. Recent literature reporting cases with chronic interstitial lung diseases which developed respiratory failure by complications with COVID-19 is also reviewed and discussed.

【 授权许可】

CC BY