The Global Prevalence of Amblyopia in Children: A Systematic Review and Meta-Analysis

Frontiers in Pediatrics

article

Budan Hu¹  Zongshun Liu¹  Jiao Zhao¹  Li Zeng¹  Gengsheng Hao¹  Dan Shui¹  Ke Mao¹ 

[1] Department of Ophthalmology, The People’s Hospital of Leshan

关键词: amblyopia;    children;    prevalence;    worldwide;    meta-analysis;   

DOI  :  10.3389/fped.2022.819998

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Epidemiological data about the prevalence of amblyopia around the world vary widely among regions and periods. This meta-analysis aimed to determine the global prevalence of amblyopia in children. PubMed, Embase, and the Cochrane Library were searched for prevalence studies published up to 5 November 2021. The outcome was the prevalence of amblyopia, analyzed as pooled estimates with 95% confidence intervals (CI). A total of 97 studies were included, including 4,645,274 children and 7,706 patients with amblyopia. The overall worldwide pooled prevalence of amblyopia was 1.36% (95%CI: 1.27–1.46%). The prevalence of amblyopia was higher in males (1.40%, 95%CI: 1.10–1.70%) than in females (1.24%, 95%CI: 0.94–1.54%) ( OR = 0.885, 95%CI: 0.795–0.985, P = 0.025). The results of the meta-regression analysis showed that there were no significant associations between the prevalence of amblyopia and geographical area, publication year, age, sample size, and whether it was carried out in a developed or developing country (all P > 0.05). Begg’s test ( P = 0.065) and Egger’s test ( P < 0.001) showed that there was a significant publication bias in the prevalence of amblyopia. In conclusion, amblyopia is a significant vision problem worldwide, and public health strategies of early screening, treatment, and management are important.

【 授权许可】

CC BY