Periodontal Disease and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis

Frontiers in Pediatrics

article

Youzhen Zhang¹  Wanbing Feng¹  Jingyu Li¹  Linlin Cui¹  Zi-Jiang Chen¹ 

[1] Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University;Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University;Shandong Key Laboratory of Reproductive Medicine;Shandong Provincial Clinical Research Center for Reproductive Health;National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics;Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

关键词: periodontal disease (PD);    neonatal outcomes;    preterm birth (PTB);    low birth weight (LBW);    meta-analysis;   

DOI  :  10.3389/fped.2022.799740

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective The aim of this study was to evaluate the association between maternal periodontal disease (PD) and three main adverse neonatal outcomes, namely, preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). Methods The Ovid Medline, Web of Science, Embase, and Cochrane Library were searched up to 6 December 2020 for relevant observational studies on an association between PD and risk of PTB, LBW, and SGA. Eligibility criteria included observational studies which compared the prevalence of PTB and/or LBW and/or SGA between PD women and periodontal health controls. The exclusion criteria included incomplete data, animal research, and mixing up various pregnancy outcomes, such as “preterm low birth weight” and languages other than Chinese and English. Data were extracted and analyzed independently by two authors. The meta-analysis was performed using Stata Statistical Software, Release 12 (StataCorp LP, College Station, TX, USA). Odds ratio (OR), confidence intervals (CIs), and heterogeneity ( I 2 ) were computed. Results Fourteen case-control studies and 10 prospective cohort studies, involving 15,278 participants, were identified. Based on fixed effect meta-analysis, PTB showed a significant association with PD (OR = 1.57, 95% CI: 1.39–1.77, P < 0.00001) and LBW also showed a significant association with PD (OR = 2.43, 95% CI: 1.75–3.37, P < 0.00001) in a random effect meta-analysis. However, a random effect meta-analysis showed no relationship between PD and SGA (OR = 1.62, 95% CI: 0.86–3.07, P = 0.136). Conclusion Our findings indicate that pregnant women with PD have a significantly higher risk of PTB and LBW. However, large prospective, blinded cohort studies with standardized diagnostic criteria of PD and adequate control of confounding factors are still required to confirm the relationship between PD and adverse neonatal outcomes.

【 授权许可】

CC BY