Myocardial fibrosis in congenital heart disease

Frontiers in Pediatrics

article

Blanca Gordon¹  Víctor González-Fernández¹  Laura Dos-Subir๠

[1] Integrated Adult Congenital Heart Disease Unit, Vall d’Hebron University Hospital—Santa Creu i Sant Pau University Hospital

关键词: myocardial fibrosis;    fibrosis;    congenital heart disease;    cardiac magnetic resonance (CMR);    collagen biomarkers;    tetralogy of Fallot;    systemic right ventricle;    myocardial interstitial fibrosis;   

DOI  :  10.3389/fped.2022.965204

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction since it distorts the normal architecture of the myocardium and impairs the biological function and properties of the interstitium. This review summarizes current knowledge on the mechanisms and detrimental consequences of myocardial fibrosis in heart failure and arrhythmias, discusses the usefulness of available imaging techniques and circulating biomarkers to assess this entity and reviews the current body of evidence regarding myocardial fibrosis in the different subsets of congenital heart diseases with implications in research and treatment.

【 授权许可】

CC BY