The role of necroptosis in common respiratory diseases in children

Frontiers in Pediatrics

article

Junjie Ning¹  Lina Qiao¹ 

[1] Pediatric Intensive Care Unit, West China Second University Hospital, Sichuan University;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University;NHC Key Laboratory of Chronobiology, Sichuan University

关键词: necroptosis;    RIPK1;    RIPK3;    MLKL;    Necrostatin-1;   

DOI  :  10.3389/fped.2022.945175

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Studies have shown that necroptosis (NEC) relies on a unique gene-regulated molecular pathway to cause cell death. With the development of knockout mouse models and specific molecular inhibitors of necrotic proteins, this cell death pathway has been considered one of the important causes of the pathogenesis of human diseases. In this review, we explored the possible roles and mechanisms of NEC in common respiratory diseases in children, such as acute lung injury, acute respiratory distress syndrome, pulmonary infection, childhood asthma, pulmonary hypertension, etc., in order to provide new ideas for the prevention and treatment of such diseases.

【 授权许可】

CC BY