Hypoplastic Left Heart Syndrome: Is There a Role for Fetal Therapy?

Frontiers in Pediatrics

article

Andreas Tulzer¹  James C. Huhta³  Julian Hochpoechler¹  Kathrin Holzer¹  Thomas Karas¹  David Kielmayer¹  Gerald Tulzer¹ 

[1] Children’s Heart Center Linz, Department of Pediatric Cardiology, Kepler University Hospital;Medical Faculty, Johannes Kepler University Linz;Perinatal Cardiology, St. Joseph Hospital

关键词: critical aortic stenosis;    hypoplastic left heart;    fetal cardiac interventions (FCI);    fetal aortic valvuloplasty;    maternal hyperoxygenation;    restrictive interatrial septum;   

DOI  :  10.3389/fped.2022.944813

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

During fetal life some cardiac defects may lead to diminished left heart growth and to the evolution of a form of hypoplastic left heart syndrome (HLHS). In fetuses with an established HLHS, severe restriction or premature closure of the atrial septum leads to left atrial hypertension and remodeling of the pulmonary vasculature, severely worsening an already poor prognosis. Fetal therapy, including invasive fetal cardiac interventions and non-invasive maternal hyperoxygenation, have been introduced to prevent a possible progression of left heart hypoplasia, improve postnatal outcome, or secure fetal survival. The aim of this review is to cover patient selection and possible hemodynamic effects of fetal cardiac procedures and maternal hyperoxygenation in fetuses with an evolving or established hypoplastic left heart syndrome.

【 授权许可】

CC BY