Progress of Pathogenesis in Pediatric Multifocal Atrial Tachycardia

Frontiers in Pediatrics

article

Huaiyang Chen¹  Yingxu Ma³  Yefeng Wang²  Haiyan Luo²  Zhenghui Xiao¹  Zhi Chen²  Qiming Liu³  Yunbin Xiao¹ 

[1] Academy of Pediatrics, University of South China;Hunan Children's Hospital;Department of Cardiology, The Second Xiangya Hospital of Central South University

关键词: multifocal atrial tachycardia (MAT);    inflammation;    autonomic nervous;    ion channel;    pathogenesis;    etiology;   

DOI  :  10.3389/fped.2022.922464

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Multifocal atrial tachycardia (MAT) is defined as irregular P-P, R-R, and P-R intervals, isoelectric baseline between P waves, and ventricular rate over 100 beats/min. Although the prognosis of pediatric MAT in most patients is favorable, adverse outcomes of MAT have been reported, such as cardiogenic death (3%), respiratory failure (6%), or persistent arrhythmia (7%), due to delayed diagnosis and poorly controlled MAT. Previous studies demonstrated that pediatric MAT is associated with multiple enhanced automatic lesions located in the atrium or abnormal automaticity of a single lesion located in the pulmonary veins via multiple pathways to trigger electrical activity. Recent studies indicated that pediatric MAT is associated with the formation of a re-entry loop, abnormal automaticity, and triggering activity. The occurrence of pediatric MAT is affected by gestational disease, congenital heart disease, post-cardiac surgery, pulmonary hypertension, and infectious diseases, which promote MAT via inflammation, redistribution of the autonomic nervous system, and abnormal ion channels. However, the pathogenesis of MAT needs to be explored. This review is aimed to summarize and analyze the pathogenesis in pediatric MAT.

【 授权许可】

CC BY