Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective

Frontiers in Pediatrics

article

Joseph Y. Ting¹  Julie Autmizguine³  Michael S. Dunn⁵  Julie Choudhury⁶  Julie Blackburn⁷  Shikha Gupta-Bhatnagar⁸  Katrin Assen²  Julie Emberley⁹  Sarah Khan^1,10  Jessica Leung^1,11  Grace J. Lin^1,12  Destiny Lu-Cleary^1,13  Frances Morin²  Lindsay L. Richter²  Isabelle Viel-Thériault^1,14  Ashley Roberts²  Kyong-soon Lee⁵  Erik D. Skarsgard^1,15  Joan Robinson^1,16  Prakesh S. Shah⁵ 

[1] Department of Pediatrics, University of Alberta;Department of Pediatrics, University of British Columbia;Division of Infectious Diseases, Department of Pediatrics, Université de Montreal;Department of Pharmacology and Physiology, Université de Montréal;Division of Neonatology, Department of Pediatrics, University of Toronto;Department of Pharmacy, Sunnybrook Health Sciences Centre;Department of Microbiology, Infectious Diseases and Immunology, Université de Montreal;Division of Neonatology, Department of Pediatrics, McMaster University;Division of Neonatology, Department of Pediatrics, University of Manitoba;Department of Microbiology, McMaster University;Department of Pediatrics, University of Massachusetts;School of Medicine, Queen's University;Northern Ontario School of Medicine;Division of Infectious Diseases, Department of Pediatrics, CHU de Québec-Université Laval;Division of Pediatric Surgery, Department of Surgery, University of British Columbia;Division of Infectious Diseases, Department of Pediatrics, University of Alberta

关键词: neonate;    sepsis;    urinary tract infection;    surgical prophylaxis;    ventilator-associated pneumonia;    necrotizing enterocolitis;    antimicrobial;   

DOI  :  10.3389/fped.2022.894005

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Neonates are highly susceptible to infections owing to their immature cellular and humoral immune functions, as well the need for invasive devices. There is a wide practice variation in the choice and duration of antimicrobial treatment, even for relatively common conditions in the NICU, attributed to the lack of evidence-based guidelines. Early decisive treatment with broad-spectrum antimicrobials is the preferred clinical choice for treating sick infants with possible bacterial infection. Prolonged antimicrobial exposure among infants without clear indications has been associated with adverse neonatal outcomes and increased drug resistance. Herein, we review and summarize the best practices from the existing literature regarding antimicrobial use in commonly encountered conditions in neonates.

【 授权许可】

CC BY