The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft

Frontiers in Pediatrics

article

Paul Luchian Aldea¹  Andreea Liana Rachisan²  Bogdan Ioan Stanciu³  Andrei Picos⁴  Alina Monica Picos⁵  Dan Ioan Delean²  Ramona Stroescu⁶  Magdalena Iuliana Starcea⁷  Cristina Maria Borzan¹  Florin Ioan Elec⁸ 

[1] Department of Community Medicine, Discipline of Public Health and Management, Iuliu Haţieganu University of Medicine and Pharmacy;Department of Mother and Child, Discipline of Pediatrics II, Iuliu Haţieganu University of Medicine and Pharmacy;Department of Radiology, Iuliu Haţieganu University of Medicine and Pharmacy;Department of Prevention in Dental Medicine, Iuliu Haţieganu University of Medicine and Pharmacy;Department of Dental Prosthetics, Iuliu Haţieganu University of Medicine and Pharmacy;Department of Pediatrics, Victor Babeş University of Medicine and Pharmacy;Department of Pediatrics, University of Medicine & Pharmacy “Grigore T. Popa”;Department of Surgical Sciences, Discipline of Urology, Iuliu Haţieganu University of Medicine and Pharmacy

关键词: cystatin C;    neutrophil gelatinase-related lipoprotein;    kidney injury molecule 1;    beta 2 microglobulin;    biomarkers;    graft function;   

DOI  :  10.3389/fped.2022.869628

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Kidney transplantation (KT) is currently the elective approach for patients with end-stage renal disease. Although it is a safe choice for these patients, the early complications can lead to graft dysfunction. One of the most redoubtable complications is delayed graft function (DGF), having no specific treatment. The effects of DGF on the graft survival are large enough to justify the formulation of specific biological protocols. Therefore, discovering biomarkers of acute impairment in renal transplanted patients is required. Creatinine is a poor marker to establish the kidney injury. Estimated glomerular filtration rate together with creatinine is ready to approximately measure the kidney function. Different serum and urine proteins are being studied as possible predictive biomarkers for delayed graft function. This review will concentrate on recent and existing research which provide insight concerning the contribution of some molecules for the estimation and evaluation of graft function after kidney transplantation. Further studies examining various aspects of DGF after KT are urgently needed to address a hitherto less-known clinical question.

【 授权许可】

CC BY