Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

Frontiers in Pediatrics

article

Marissa J. DeFreitas¹  Chryso P. Katsoufis¹  Merline Benny²  Karen Young²  Shathiyah Kulandavelu¹  Hyunyoung Ahn⁵  Anna Sfakianaki⁵  Carolyn L. Abitbol¹ 

[1] Division of Pediatric Nephrology, Department of Pediatrics, University of Miami;Department of Pediatrics, Batchelor Children’s Research Institute, University of Miami;Division of Neonatology, Department of Pediatrics, University of Miami;Interdisciplinary Stem Cell Institute, University of Miami;Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami

关键词: oxidative stress;    preterm birth;    kidney development;    hypoxia;    hyperoxia;   

DOI  :  10.3389/fped.2022.853722

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.

【 授权许可】

CC BY