Meta-Analysis of the Safety and Efficacy of α-Adrenergic Blockers for Pediatric Urolithiasis in the Distal Ureter

Frontiers in Pediatrics

article

Fengze Sun¹  Xingjun Bao²  Dongsheng Cheng³  Huibao Yao¹  Kai Sun¹  Di Wang¹  Zhongbao Zhou⁴  Jitao Wu¹ 

[1] Department of Urology, Yantai Yuhuangding Hospital, Qingdao University;The Second Clinical Medical College, Binzhou Medical University;Department of Pharmacy, Yantai Yuhuangding Hospital, Qingdao University;Department of Urology, Beijing Tiantan Hospital, Capital Medical University

关键词: alpha-adrenergic blockers;    tamsulosin;    silodosin;    doxazosin;    pediatric urolithiasis;    meta-analysis;    distal ureteral stones;    randomized controlled trials;   

DOI  :  10.3389/fped.2022.809914

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective Pediatric urolithiasis is a common condition, and medical expulsive therapy has grown to be accepted by many parents. We carried out a meta-analysis to identify the efficacy and safety of α-adrenergic blockers for the treatment of pediatric urolithiasis. Methods We identified related articles from the PubMed, Embase, and Cochrane Library databases. All published randomized controlled trials (RCTs) describing the use of α-adrenergic blockers and placebo treatment for pediatric distal urolithiasis were involved. The outcomes included stone expulsion rate, stone expulsion time, pain episodes, need for analgesia, adverse events, and related subgroup analyses. Results A total of nine RCTs were involved in our study, including 586 patients. We found that α-adrenergic blockers could significantly increase the rate of stone expulsion [odds ratio (OR), 3.49; 95% confidence interval (CI), 2.38–5.12; p 5 mm in expulsion time (MD, −3.61; 95% CI, −10.17 to 2.96; p = 0.28). Conclusion Our review suggests that α-adrenergic blockers are well-tolerated and efficient for treating pediatric distal urolithiasis. We also conclude that silodosin is the best choice of drug, offering a better expulsion rate, but it remains to be evaluated further by future studies.

【 授权许可】

CC BY