期刊论文详细信息
Frontiers in Pediatrics
Hemostatic Evaluation With Viscoelastic Coagulation Monitor: A Nicu Experience
article
Giacomo Simeone Amelio1  Genny Raffaeli1  Ilaria Amodeo1  Silvia Gulden1  Valeria Cortesi1  Francesca Manzoni1  Nicola Pesenti1  Stefano Ghirardello1  Fabio Mosca1  Giacomo Cavallaro1 
[1] Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;Department of Clinical Sciences and Community Health, Università Degli Studi di Milano;Division of Biostatistics, Department of Statistics and Quantitative Methods, Epidemiology, and Public Health, University of Milano-Bicocca;Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo
关键词: thromboelastography;    hemostasis;    hemorrhage;    VCM;    newborn;   
DOI  :  10.3389/fped.2022.910646
学科分类:社会科学、人文和艺术(综合)
来源: Frontiers
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【 摘 要 】

Background Viscoelastic coagulation tests provide valuable information in neonatal intensive care units (NICUs), but the lack of reference intervals still limits their decision-making power according to gestational age. The aim of the present study is to evaluate the hemostasis of a cohort of full-term (FT) and late-preterm (LP) infants using the viscoelastic coagulation monitor (VCM®) system, a new portable device that uses untreated whole blood. Methods An observational study was performed to identify non-coagulopathic FT and LP infants admitted to III° level NICU (January 2020 to December 2021) with a VCM test in the first 72 h of life. Results Forty-five patients were enrolled, 26 FT and 19 LP. No statistical differences in hemostatic parameters were observed between FT and LP nor between stable and unstable neonates. Clotting time (CT) was positive correlated with PT ( p = 0.032), not with aPTT ( p = 0.185). From linear regression, platelet resulted associated with: clot formation time (CTF, p = 0.003), alpha angle (Alpha, p = 0.010), amplitude at 10 (A10, p = 0.001), amplitude at 20 min (A20, p < 0.001), maximum clot firmness (MCF, p < 0.001); and fibrinogen was associated with: A10 ( p = 0.008), A20 ( p = 0.015) and MCF ( p = 0.024). Compared to the adult reference population, neonates showed shorter CT (mean (SD): 5.3 (1.4) vs. 7.0 (0.9) min, p < 0.001), CFT (2.4 (0.7) vs. 2.8 (0.6) minutes, p < 0.001) and higher Alpha (60.8 (6.3) vs. 55 (5)°, p < 0.001). In addition, the neonatal cohort showed an early transient difference in amplitude and fibrinolysis, as follows: A10 (28.0 (5.0) vs. 26 (4) VCM units, p =0.004), A20 (34.8 (5.0) vs. 33 (4) VCM units, p =0.012), and LI30 (99.8 (0.5) vs. 99 (1)%, p <0.001). Conclusions The viscoelastic profile of FT and LP infants assessed with VCM showed a hemostatic competence characterized by accelerated coagulation and clot formation time, in line with other viscoelastic techniques. VCM system provides promising applications in the NICU setting.

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