Respiratory Oscillometry in Newborn Infants: Conventional and Intra-Breath Approaches

Frontiers in Pediatrics

article

Bence L. Radics¹  Zita Gyurkovits²  Gergely Makan³  Zoltán Gingl³  Dorottya Czövek⁴  Zoltán Hantos⁵ 

[1] Department of Pathology, University of Szeged;Department of Obstetrics and Gynecology, University of Szeged;Department of Technical Informatics, University of Szeged;1st Department of Pediatrics, Semmelweis University;Department of Anesthesiology and Intensive Therapy, Semmelweis University

关键词: infant oscillometry;    respiratory resistance;    respiratory reactance;    respiratory compliance;    nasal resistance;    intra-breath method;   

DOI  :  10.3389/fped.2022.867883

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Oscillometry has been employed widely as a non-invasive and standardized measurement of respiratory function in children and adults; however, limited information is available on infants. Aims To establish the within-session variability of respiratory impedance (Zrs), to characterize the degree and profile of intra-breath changes in Zrs and to assess their impact on conventional oscillometry in newborns. Methods 109 healthy newborns were enrolled in the study conducted in the first 5 postpartum days during natural sleep. A custom-made wave-tube oscillometry setup was used, with an 8–48 Hz pseudorandom and a 16 Hz sinusoidal signal used for spectral and intra-breath oscillometry, respectively. A resistance-compliance-inertance (R-C-L) model was fitted to average Zrs spectra obtained from successive 30-s recordings. Intra-breath measures, such as resistance (Rrs) and reactance (Xrs) at the end-expiratory, end-inspiratory and maximum-flow points were estimated from three 90-s recordings. All natural and artifact-free breaths were included in the analysis. Results Within-session changes in the mean R, C and L values, respectively, were large (mean coefficients of variation: 10.3, 20.3, and 26.6%); the fluctuations of the intra-breath measures were of similar degree (20–24%). Intra-breath analysis also revealed large swings in Rrs and Xrs within the breathing cycle: the peak-to-peak changes amounted to 93% (range: 32–218%) and 41% (9–212%), respectively, of the zero-flow Zrs magnitude. Discussion Intra-breath tracking of Zrs provides new insight into the determinants of the dynamics of respiratory system, and highlights the biasing effects of mechanical non-linearities on the average Zrs data obtained from the conventional spectral oscillometry.

【 授权许可】

CC BY