Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children

Frontiers in Pediatrics

article

Minyee Ong¹  Le Duc Huy Ta²  Hui Xing Lau¹  Michelle Jia Yu Tay²  Qai Ven Yap³  Yiong Huak Chan³  Elizabeth Huiwen Tham¹  Anne Eng Neo Goh⁶  Hugo Van Bever²  Oon Hoe Teoh⁷  Johan Gunnar Eriksson¹  Yap Seng Chong¹  Peter Gluckman¹  Evelyn Xiu Ling Loo¹  Delicia Shu Qin Ooi²  Fabian Kok Peng Yap^1,11  Neerja Karnani¹  Jia Xu¹  Karen Mei Ling Tan¹  Kok Hian Tan^1,16  Bee Wah Lee²  Michael Kramer⁸  Lynette Pei-chi Shek²  Michael J. Meaney¹  Birit F. P. Broekman¹ 

[1] Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore;Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore;Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore;Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System;Allergy Service, Department of Paediatrics, KK Women’s and Children’s Hospital;Respiratory Service, Department of Paediatrics, KK Women’s and Children’s Hospital;Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System;Folkhälsan Research Center, Faculty of Medicine, University of Helsinki;Liggins Institute, University of Auckland;Duke-NUS Medical School;Lee Kong Chian School of Medicine, Nanyang Technological University;Endocrinology Service, Department of Paediatrics, KK Women’s and Children’s Hospital;Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore;Bioinformatics Institute, Agency for Science, Technology and Research;Department of Maternal Fetal Medicine, KK Women’s and Children’s Hospital;Department of Pediatrics and of Epidemiology and Biostatistics, McGill University Faculty of Medicine;Sackler Program for Epigenetics & Psychobiology at McGill University;Ludmer Centre for Neuroinformatics and Mental Health, McGill University;Department of Psychiatry, McGill University;Department of Psychiatry, OLVG and Amsterdam UMC, VU University

关键词: atopy;    attention deficit hyperactivity disorder;    cytokines;    eczema;    gut microbiome dysbiosis;   

DOI  :  10.3389/fped.2022.837741

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Epidemiological studies suggest a link between eczema and attention deficit hyperactivity disorder (ADHD), but underlying mechanisms have not been examined. Objective We aim to investigate the association between eczema and subsequent ADHD symptoms in the Growing Up in Singapore Towards healthy Outcomes cohort and explore the role of pro-inflammatory cytokines and gut microbiome. Methods The modified International Study of Asthma and Allergies in Childhood questionnaire and Computerized Diagnostic Interview Schedule for Children Version IV were administered to assess reported eczema within the first 18 months and presence of ADHD symptoms at 54 months, respectively. Skin prick testing at 18 months, cytokines in maternal blood during pregnancy and cord blood and the mediating role of the gut microbiome at 24 months were assessed. Results After adjusting for confounders, eczema with or without a positive skin prick test was associated with doubling the risk of ADHD symptoms. No differences in maternal and cord blood cytokines were observed in children with and without eczema, or children with and without ADHD. Gut microbiome dysbiosis was observed in children with eczema and children with ADHD. Children with eczema also had lower gut bacterial Shannon diversity. However, the relationship between eczema and ADHD was not mediated by gut microbiome. Conclusion Early life eczema diagnosis is associated with a higher risk of subsequent ADHD symptoms in children. We found no evidence for underlying inflammatory mechanism or mediation by gut microbiome dysbiosis. Further research should evaluate other mechanisms underlying the link between eczema and ADHD.

【 授权许可】

CC BY