Case Report: DRESS Syndrome Induced by Two Antituberculosis Drugs in an 8-Year-Old Girl

Frontiers in Pediatrics

article

Vaidotas Urbonas¹  Dominykas Varnas¹  Kristina Mociskiene¹  Violeta Kvedariene¹  Odilija Rudzeviciene¹ 

[1] Vilnius University Faculty of Medicine Clinic of Children's Diseases

关键词: dress;    drug reaction with eosinophilia and systemic symptoms;    pediatric;    drug reaction;    antituberculosis drugs;   

DOI  :  10.3389/fped.2022.830611

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

DRESS syndrome is defined as drug-induced hypersensitivity syndrome with rash, eosinophilia, and systemic symptoms. This syndrome is mostly associated with anticonvulsants, antibacterial and anti-inflammatory drugs. DRESS syndrome is a rare disease and is more frequently seen in adults. We present the first case report of DRESS syndrome in an 8-year-old girl, after 3 months of treatment with isoniazid and rifampicin. After discontinuation of drugs and a short course of prednisolone the girl recovered. After 5 years of follow-up, she is healthy and has no complaints but patch tests with isoniazid and rifampicin remain positive. The reported case emphasizes the importance of thorough medical history and including drug reactions in differential diagnosis.

【 授权许可】

CC BY