Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements

Frontiers in Pediatrics

article

Alexandre O. Gérard¹  Audrey Fresse²  Myriam Gast³  Diane Merino²  Pierre Gourdan⁴  Audrey Laurain¹  Irène Margaritis⁵  Pierre-Alexis Gauci⁶  Fanny Huret⁵  Nadège Parassol²  Fanny Rocher² 

[1] Department of Nephrology-Dialysis-Transplantation, Centre Hospitalier Universitaire de Nice;Department of Pharmacology and Pharmacovigilance Center of Nice, Centre Hospitalier Universitaire de Nice;Department of Pediatry, Hospital Center of Bastia;Department of Pediatry, Lenval Hospital - Centre Hospitalier Universitaire de Nice;Nutrition Risk Assessment Unit, French Agency for Food, Environmental and Occupational Health & Safety;Department of Gynecology, Centre Hospitalier Universitaire de Nice

关键词: vitamin D;    overdose;    intoxication;    dietary supplement;    hypercalcemia;    pharmacovigilance;    misuse;    case report;   

DOI  :  10.3389/fped.2022.816965

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Vitamin D supplementation is routinely introduced in infants, according to medical guidelines. However, vitamin D overdose can result in life-threatening hypercalcemia. We report the case of a 3-month-old infant who suffered from severe hypercalcemia. Upon detailed questioning of the parents, a vitamin D administration error has been identified. Indeed, the parents had followed the advice of their midwife. They substituted the prescribed medicinal vitamin D by a dietary supplement, different in concentration and dosing, without performing the dose conversion needed. In fact, many different medications and dietary supplements with vitamin D exist, offering various concentrations and units of measurement. This case highlights the pivotal role of therapeutic education. Broadly, there is a need for harmonization of the regulation and labeling of dietary supplements and medications containing vitamin D.

【 授权许可】

CC BY