Lipoprotein(a) in Cardiovascular Diseases: Insight From a Bibliometric Study

Frontiers in Public Health

article

David Šuran¹  Helena Blažun Vošner³  Jernej Završnik³  Peter Kokol²  Andreja Sinkovič²  Vojko Kanič¹  Marko Kokol⁶  Franjo Naji¹  Tadej Završnik¹ 

[1] Department of Cardiology and Angiology, University Medical Centre Maribor;Faculty of Medicine, University of Maribor;Community Healthcare Centre Dr. Adolf Drolc Maribor;Faculty of Health and Social Sciences Slovenj Gradec;Alma Mater Europaea;Faculty of Electrical Engineering and Computer Science, University of Maribor;Department of Medical Intensive Care, University Medical Centre Maribor;Semantika Research

关键词: lipoprotein(a);    bibliometrics;    synthetic knowledge synthesis;    atherosclerosis;    cardiovascular disease;    inflammation;    post-menopausal women;    calcific aortic valve stenosis;   

DOI  :  10.3389/fpubh.2022.923797

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Lipoprotein(a) [Lp(a)] is a complex polymorphic lipoprotein comprised of a low-density lipoprotein particle with one molecule of apolipoprotein B100 and an additional apolipoprotein(a) connected through a disulfide bond. The serum concentration is mostly genetically determined and only modestly influenced by diet and other lifestyle modifications. In recent years it has garnered increasing attention due to its causal role in pre-mature atherosclerotic cardiovascular disease and calcific aortic valve stenosis, while novel effective therapeutic options are emerging [apolipoprotein(a) antisense oligonucleotides and ribonucleic acid interference therapy]. Bibliometric descriptive analysis and mapping of the research literature were made using Scopus built-in services. We focused on the distribution of documents, literature production dynamics, most prolific source titles, institutions, and countries. Additionally, we identified historical and influential papers using Reference Publication Year Spectrography (RPYS) and the CRExplorer software. An analysis of author keywords showed that Lp(a) was most intensively studied regarding inflammation, atherosclerosis, cardiovascular risk assessment, treatment options, and hormonal changes in post-menopausal women. The results provide a comprehensive view of the current Lp(a)-related literature with a specific interest in its role in calcific aortic valve stenosis and potential emerging pharmacological interventions. It will help the reader understand broader aspects of Lp(a) research and its translation into clinical practice.

【 授权许可】

CC BY