Gut Bacteria Erysipelatoclostridium and Its Related Metabolite Ptilosteroid A Could Predict Radiation-Induced Intestinal Injury

Frontiers in Public Health

article

Shang Cai¹  Yongqiang Yang¹  Yuehong Kong¹  Qi Guo¹  Yingying Xu¹  Pengfei Xing¹  Yanze Sun¹  Jianjun Qian¹  Ruizhe Xu¹  Liwei Xie¹  Yijia Hu¹  Min Wang⁴  Ming Li⁵  Ye Tian¹  Weidong Mao¹ 

[1] Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University;Institute of Radiotherapy and Oncology, Soochow University;Suzhou Key Laboratory for Radiation Oncology;Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University;State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University

关键词: radiation-induced intestinal injury;    biomarker;    gut bacteria;    gut bacteria related metabolite;    radiotherapy;   

DOI  :  10.3389/fpubh.2022.862598

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

It is difficult to study the intestinal damage induced by space radiation to astronauts directly, and few prediction models exist. However, we can simulate it in patients with pelvic tumor radiotherapy (RT). Radiation-induced intestinal injury (RIII) is common in cancer patients who receieved pelvic and abdominal RT. We dynamically analyzed gut microbiota and metabolites alterations in 17 cervical and endometrial cancer patients after pelvic RT. In patients who later developed grade 2 RIII, dysbiosis of gut microbiota and metabolites were observed. Univariate analysis showed that Erysipelatoclostridium and ptilosteroid A were related to the occurrence of grade 2 RIII. Notably, a strong positive correlation between gut bacteria Erysipelatoclostridium relative abundance and gut metabolite ptilosteroid A expression was found. Furthermore, combinations of Erysipelatoclostridium and ptilosteroid A could provide good diagnostic markers for grade 2 RIII. In conclusion, gut bacteria Erysipelatoclostridium and its related metabolite ptilosteroid A may collaboratively predict RIII, and could be diagnostic biomarkers for RIII and space radiation injury.

【 授权许可】

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