A Study on Pregenomic RNA and Factors Related to Hepatitis B Virus Infection Based on Real World

Frontiers in Public Health

article

Hao-Zhen Yan¹  Zhi-Hao Huang¹  Xu-Guang Guo³  Ting-Ting Peng¹  Li-Li Yang¹  Chong-Wen Liu¹  Shi Ou-Yang¹ 

[1] Department of Infectious Diseases, The Fifth Affiliated Hospital of Guangzhou Medical University;School of Public Health, Department of Preventive Medicine, Guangzhou Medical University;Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University

关键词: pregenomic RNA;    hepatitis B virus;    FIB-4;    tenofovir;    entecavir;   

DOI  :  10.3389/fpubh.2022.856103

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective This article aims to study the influencing factors of pgRNA and its change magnitude based on the real world. Methods A total of 421 patients who were tested for pgRNA were selected. According to the baseline data, the subjects were divided into negative and positive groups. The Chi-square test and logistic regression were used to analyze the influencing factors of pgRNA status. Based on the follow-up data, the rank-sum test and linear regression were used to analyze the influencing factors of pgRNA change magnitude. Results A total of 153 (36.3%) of the 421 subjects were pgRNA-negative and 268 (63.7%) were pgRNA-positive. Logistic regression analysis showed that positive HBV DNA (OR: 40.51), positive HBeAg (OR: 66.24), tenofovir treatment (OR: 23.47), and entecavir treatment (OR: 14.90) were the independent risk factors for positive pgRNA. Univariate linear regression showed that the pgRNA change magnitude of patients treated with entecavir was higher than that of patients treated with tenofovir. Multivariate linear regression showed that age was an independent factor influencing pgRNA change magnitude. Conclusions The pgRNA of patients who were young, female, HBV DNA-positive, high-HBsAg, HBeAg-positive is higher than the detection line. HBV DNA and HBeAg are the independent risk factors of positive pgRNA. Different antiviral regimens and disease stages have significantly different effects on pgRNA status. There was a significant correlation between pgRNA and FIB-4, suggesting that pgRNA is related to liver fibrosis. The decrease in pgRNA was greater in young patients than in non-young patients. The decrease in pgRNA was greater in patients treated with tenofovir than in patients treated with entecavir.

【 授权许可】

CC BY