Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India

Frontiers in Public Health

article

Jeromie Wesley Vivian Thangaraj¹  Muthusamy Santhosh Kumar¹  C. P. Girish Kumar¹  Pragya Yadav²  D. Sudha Rani¹  T. Karunakaran¹  Manoj Murhekar¹ 

[1] ICMR-National Institute of Epidemiology;ICMR-National Institute of Virology

关键词: SARS-CoV-2;    reinfection;    IgG antibody;    genomic sequencing;    COVID-19;   

DOI  :  10.3389/fpubh.2022.836454

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobulin G (IgG) antibodies to estimate the extent of re-infection. Of the 902 unvaccinated COVID-19 positive individuals, 53 (26.5%) were reactive for IgG antibodies and non-reactive for Immunogobulin M (IgM) antibodies. Among the 53 IgG-positive individuals, the interval between symptom onset (or last contact with the known case in case of asymptomatic) was <5 days in 29 individuals, ≥5 days in 11 individuals, while 13 asymptomatic individuals did not know their last contact with a positive case. The possible re-infections ranged between 3.2% (95% CI: 2.2–4.5%) and 4.3% (95% CI: 3.4–6.2%). The findings indicate that re-infection was not a major reason of the surge in cases during second wave. The IgG seropositivity among recently diagnosed unvaccinated COVID-19 patients could provide early indications about the extent of re-infections in the area.

【 授权许可】

CC BY