Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China

Frontiers in Public Health

article

Mengmeng Wu¹  Fangzhao Ming³  Songjie Wu⁴  Yanbin Liu¹  Xiaoxia Zhang¹  Wei Guo⁵  Gifty Marley⁷  Weiming Tang⁸  Ke Liang¹ 

[1] Department of Infectious Diseases, Zhongnan Hospital of Wuhan University;Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences;Wuchang District Center for Disease Control and Prevention;Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University;Department of Pathology, Zhongnan Hospital of Wuhan University;Department of Pathology, School of Basic Medical Sciences, Wuhan University;School of Public Health of Nanjing Medical University;Guangdong Second Provincial Central Hospital, Southern Medical University;University of North Carolina at Chapel Hill Project-China;Hubei Engineering Center for Infectious Disease Prevention

关键词: SARS-CoV-2;    people living with human immunodeficiency virus (PLWH);    IgG;    IgM;    asymptomatic infectors;    symptomatic patient;   

DOI  :  10.3389/fpubh.2022.833783

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background In the era of the COVID-19 pandemic, people living with HIV (PLWH) face more challenges. However, it is unclear if PLWH is more susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than HIV-negative individuals. This study aimed to explore the prevalence of the SARS-CoV-2 infection and the associated risk factors among PLWH. Methods From 1 to 30 May 2020, we conducted a cross-sectional survey that enrolled 857 PLWH and 1,048 HIV-negative individuals from the Wuchang district in Wuhan, China. Our data analysis compared the rate of the SARS-CoV-2 infection among PLWH and HIV-negative participants, and the proportions of symptomatic patients and asymptomatic infectors between the two groups. We also assessed the risk factors associated with the SARS-CoV-2 infection among PLWH. Results Overall, 14/857 (1.6%) PLWH and 68/1,048 (6.5%) HIV-negative participants were infected with SARS-CoV-2. Among the SARS-CoV-2-infected PLWH participants, 6/14 (42.8%) were symptomatic patients, 4/14 (28.6%) were SARS-CoV-2 nucleic acid-positive asymptomatic infectors, and 4/14 (28.6%) were serology-positive asymptomatic infectors. Among the infected HIV-negative participants, 5/68 (7.4%) patients were symptomatic and 63/68 (92.6%) were serology-positive asymptomatic infectors. The rate of the SARS-CoV-2 infection was lower among the PLWH than in the HIV-negative group (1.96% vs. 5.74%, p = 0.001) and the rate of morbidity among the symptomatic patients was similar between the two groups ( p = 0.107). However, there were more serology-positive asymptomatic infectors among the infected HIV-negative participants than among the infected PLWH (0.54% vs. 5.46%, p = 0.001). Furthermore, being 50 years or older (aOR = 4.50, 95% CI: 1.34–15.13, p = 0.015) and having opportunistic infections (aOR = 9.59, 95% CI: 1.54–59.92, p = 0.016) were associated with an increased risk of SARS-CoV-2 infection among PLWH. Conclusions PLWH has more varied forms of the SARS-CoV-2 infection than the HIV-negative population and should, therefore, undertake routine screening to avoid late diagnosis. Also, older age (≥50 years) and having opportunistic infections increase the risks of SARS-CoV-2 infection among PLWH.

【 授权许可】

CC BY