Arsenic Speciation and Metallomics Profiling of Human Toenails as a Biomarker to Assess Prostate Cancer Cases: Atlantic PATH Cohort Study

Frontiers in Public Health

article

Erin Keltie¹  Kalli M. Hood¹  Yunsong Cui³  Ellen Sweeney³  Gabriela Ilie¹  Anil Adisesh⁴  Trevor Dummer⁶  Veni Bharti¹  Jong Sung Kim¹ 

[1] Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University;Health and Environments Research Centre ,(HERC) Laboratory, Faculty of Medicine, Dalhousie University;Atlantic Partnership for Tomorrow's Health ,(PATH), Dalhousie University;Division of Occupational Medicine, Department of Medicine, University of Toronto;Department of Medicine, Dalhousie Medicine New Brunswick;School of Population and Public Health, University of British Columbia

关键词: arsenic exposure;    metallome;    speciation;    toenail biomarker;    prostate cancer;    cohort study;   

DOI  :  10.3389/fpubh.2022.818069

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Chronic exposure to inorganic arsenic and trace metals has been linked to prostate cancer, and altered arsenic methylation capacity may have an important role in arsenic carcinogenesis. Biomarkers may be able to elucidate this role. Our objectives were to characterize profiles of arsenic species and metallome in toenails and urine samples, compare profiles between prostate cancer cases and controls, and determine the discriminant ability of toenail and urine biomarkers. Toenail samples ( n = 576), urine samples ( n = 152), and questionnaire data were sourced from the Atlantic Partnership for Tomorrow's Health (PATH) cohort study. Healthy controls were matched to prostate cancer cases (3:1 ratio) on sex, age, smoking status, and the province of residence. Metallome profiles and proportions of arsenic species were measured in toenail and urine samples. Analysis of covariance (ANCOVA) was used to compare the mean percent monomethylarsonic acid (%MMA), dimethylarsonic acid (%DMA), inorganic arsenic (%iAs), primary methylation index (PMI, MMA/iAs), and secondary methylation index (SMI, DMA/MMA). Multivariate analysis of covariance (MANCOVA) was used to compare selected metal concentrations. Mean %MMA was significantly lower and SMI was significantly higher in toenails from prostate cancer cases compared to controls in unadjusted and adjusted models. Proportions of arsenic species were correlated with total arsenic in toenails. Arsenic speciation in urine was not different between cases and controls, nor were metallome profiles in toenails and urine. Our results indicate that toenails are a viable biomarker for altered arsenic speciation in prostate cancer cases and may have greater utility than urine in this context.

【 授权许可】

CC BY