Influence of Demographic Factors on Long-Term Trends of Premature Mortality and Burden Due to Liver Cancer: Findings From a Population-Based Study in Shanghai, China, 1973–2019

Frontiers in Public Health

article

Zheng Luo¹  Yongbin Zou²  Jiaxin Xie³  Hui Cao²  Yichen Chen⁴  Yibo Ding⁵  Xiaopan Li⁴  Yang Deng⁶  Lile Wu⁷ 

[1] Department of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital;Department of Oncology, Chenzhou First People's Hospital;Department of High Altitude Operational Medicine, Army Medical University;Center for Disease Control and Prevention of Pudong New Area, Fudan University Pudong Institute of Preventive Medicine;Department of Epidemiology, Second Military Medical University;School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences;Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University

关键词: liver cancer;    mortality;    years of life lost;    difference decomposition method;    demographic factors;   

DOI  :  10.3389/fpubh.2022.808917

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective Liver cancer is one of the most common causes of cancer-related death. Understanding how demographic factors influence mortality due to liver cancer is crucial for optimizing disease-control strategies. We aimed to characterize the long-term trends in the mortality and years of life lost (YLL) of liver cancer in Shanghai, China, 1973–2019, and quantitatively analyze the contributions of demographic and non-demographic factors on the mortality of liver cancer. Methods Using mortality data from the Mortality Registration System of Pudong New Area, the largest district of Shanghai with a population of permanent resident of 5.68 million, during 1973–2019, we analyzed the temporal trends for the mortality rates and YLL by Joinpoint Regression Program. The difference decomposition method was employed to estimate the increasing mortality rates related to demographic and non-demographic factors. Results A total of 21,530 deaths from liver cancer occurred from 1973 to 2019. The crude mortality rates (CMR) and age-standardized mortality rate by Segi's world standard population (ASMRW) of liver cancer were 26.73/10 5 person-years and 15.72/10 5 person-years, respectively. The CMR, ASMRW, and YLL rates of liver cancer showed significantly decreasing trends in males, females and the total population from 1973 to 2019, whereas the upward trends in the YLL were seen in males, females and the total population (all P < 0.05). A significant upward trend was observed in the increased CMR caused by demographic factors, but the changing rate caused by non-demographic factors decreased. Conclusions The CMR and ASMRW of liver cancer continually decreased although YLL increased during 1973–2019 in Pudong New Area, Shanghai. The demographic factors, especially aging, might be responsible for the increase in the mortality of liver cancer. More effective prevention strategies tailored to liver cancer are needed to further reduce its disease burden in the elderly population.

【 授权许可】

CC BY