Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report

Frontiers in Public Health

article

Joanna Bokel¹  Daniela P. Mendes-de-Almeida¹  Remy Martins-Gonçalves⁴  Lohanna Palhinha⁴  Alexandre G. Vizzoni¹  Danusa Ferreira Correa⁵  Luciana Gomes Pedro Brandão⁵  Patrícia T. Bozza⁴  Beatriz Grinsztejn⁶ 

[1] Department of Hematology, Instituto Nacional de Infectologia Evandro Chagas;Onco-Hematology Unit;Research Center, Instituto Nacional de Câncer;Laboratory of Immunopharmacology, Instituto Oswaldo Cruz;Health Surveillance and Immunization Research Unit, Instituto Nacional de Infectologia Evandro Chagas;Laboratory of Clinical Research on STD/AIDS, Instituto Nacional de Infectologia Evandro Chagas

关键词: generalized edema;    pseudothrombocytopenia;    spurious thrombocytopenia;    COVID-19 vaccine safety;    vaccine-induced pseudothrombocytopenia;   

DOI  :  10.3389/fpubh.2022.907652

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Reports of side effects of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak syndrome and vaccine-induced immune thrombotic thrombocytopenia are very rare but life-threatening adverse events that should be identified early and treated. However, isolated thrombocytopenia can indicate pseudothrombocytopenia. In certain people, ethylenediaminetetraacetic acid (EDTA) induces an in vitro platelet aggregation, resulting in misleading underestimation of platelet counts. It is essential to recognize pseudothrombocytopenia to prevent diagnostic errors, overtreatment, anxiety, and unnecessary invasive procedures. We present a case who developed generalized edema and persistent pseudothrombocytopenia after the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca).

【 授权许可】

CC BY