Clinicopathological and Prognostic Value of USP22 Expression in Gastric Cancer: A Systematic Review and Meta-Analysis and Database Validation

Frontiers in Surgery

article

Yuhang Wang¹  Zirui Jia¹  Jiacheng Gao¹  Tingting Zhou³  Xiangwen Zhang¹  Guo Zu¹ 

[1] Department of General Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University;Department of Graduate School, Dalian Medical University;Department of Neurology, The First Affiliated Hospital of Dalian Medical University

关键词: USP22;    gastric cancer;    overall survival;    clinicopathological parameters;    meta-analysis;   

DOI  :  10.3389/fsurg.2022.920595

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background It has been reported that there is a correlation between the level of ubiquitin-specific protease 22 (USP22) and the clinicopathological parameters and prognosis of gastric cancer (GC) patients, but the conclusions are inconsistent. Hence, a meta-analysis must be conducted to clarify the relationship between USP22 expression and clinicopathological and prognostic value of GC patients to provide more accurate evidence. Methods According to the predetermined selection criteria, systematic file retrieval was performed. The hazard ratio (HR) or odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the relationship between USP22 expression and clinicopathological and prognostic value of GC patients. Results In a total of 802 patients, those with GC were finally included in 6 studies. The pooled results demonstrated that the expression of USP22 was significantly increased in GC tissues compared with control tissues (OR = 9.947, 95% CI, 6.074–16.291, P  = 0.000), and USP22 expression was related to lymph node metastasis (OR = 2.415, 95% CI, 1.082, P  = 0.031), distant metastasis (OR = 3.956, 95% CI, 1.365–11.464, P  = 0.011) and TNM stage (OR = 2.973, 95% CI, 1.153–7.666, P  = 0.024). Nevertheless, the expression of USP22 was not correlated with gender (OR = 1.202, 95% CI, 0.877–1.648, P  = 0.253), age (OR = 1.090, 95% CI, 0.811–1.466, P  = 0.568), tumor size (OR = 0.693,95% CI, 0.348–1.380, P  = 0.297), tumor differentiation (OR = 1.830, 95%CI, 0.948–3.531, P  = 0.072) and depth of invasion (OR = 2.320, 95% CI, 0.684–7.871, P  = 0.177). Moreover, a high expression of USP22 predicted a poor overall survival (OS) in GC patients (HR = 2.012, 95% CI, 1.522–2.658, P  = 0.000). The database of Kaplan–Meier plotter confirmed that a high expression of USP22 was correlated with poor prognostics in GC patients (HR = 1.41, 95% CI, 1.18–1.68, P  < 0.01). Conclusion USP22 overexpression in GC tissues is positively related to lymph node metastasis, distant metastasis and TNM stage and indicates a poor clinical outcome of GC patients, but it is not associated with age, gender, depth of invasion, tumor differentiation and tumor size of GC patients.

【 授权许可】

CC BY