Prediction of Long-Term Survival Outcome by Lymph Node Ratio in Patients of Parotid Gland Cancer: A Retrospective study

Frontiers in Surgery

article

Wen-Mei Jiang¹  Jian-Feng Xu²  Jun Chen¹  Guo-Li Li¹  Yun-Fei Gao³  Quan Zhang¹  Yan-Feng Chen¹ 

[1] Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine;Department of Surgery, Dongguan Third Bureau Hospital;Department of Otolaryngology, The Seventh Affiliated Hospital of Sun Yat-sen University

关键词: Parotid gland cancer;    lymph node ratio;    survival;    stage I–IV;    SEER;   

DOI  :  10.3389/fsurg.2022.903576

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background Lymph node ratio (LNR) has been reported to reliably predict cancer-specific survival (CSS) in parotid gland cancer (PGC). Our study was designed to validate the significance of LNR in patients with PGC. Methods Patients diagnosed with stage I–IV PGC were enrolled from Surveillance Epidemiology and End Results database (SEER, N  = 3529), which is the training group, and Sun Yat-sen University Cancer Center database (SYSUCC, N  = 99), the validation group. We used X-tile software to choose the optimal cutoff value of LNR; then, univariable and multivariable analyses were performed, assessing the association between LNR and CSS. Results The optimal cutoff value of LNR was 0.32 by X-tile based on 3529 patients from SEER. Cox proportional hazard regression analysis revealed better CSS for patients with LNR ≤ 0.32 (adjusted hazard ratio [HR] 1.612, 95% confidence interval [95% CI] 1.286–2.019; p   0.32 in SEER. In the SYSUCC cohort, patients with LNR ≤ 0.32 also had better CSS over patients with LNR > 0.32 ( p   0.32 group, but this benefit was absent in the N1 stage group. Conclusions In conclusion, the lymph node ratio turned out to be an independent prognostic factor for cancer-specific survival of PGC in this study. This valuable information could help clinicians to evaluate the prognosis of PGC and suggest that adequate lymph node dissection is necessary.

【 授权许可】

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