GATA3 Predicts the Tumor Microenvironment Phenotypes and Molecular Subtypes for Bladder Carcinoma

Frontiers in Surgery

article

Qixin Zhang¹  Tiezheng Qi²  Yu Long¹  Xiaowen Li²  Yiyan Yao²  Qi Wu¹  Anrong Zou¹  Belaydi Qthmane³  Peihua Liu³ 

[1] Department of Urology, Ping Kuang General Hospital;Xiangya School of Medicine, Central South University;Department of Urology, Xiangya Hospital, Central South University;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital

关键词: GATA3;    bladder cancer;    tumor microenvironment;    immunotherapy;    risk score;    chemotherapy;   

DOI  :  10.3389/fsurg.2022.860663

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Aims GATA3 is a key player in antitumor immunology, and continuous studies show that it might be a key biomarker for bladder cancer (BLCA). Thus, we lucubrate the immunological role of GATA3 in BLCA. Main Methods We initially used pan-cancer analysis to analyze the expression pattern and immunological function of GATA3 with data gathered from the TCGA (The Cancer Genome Atlas). Then, in the BLCA tumor microenvironment (TME), we comprehensively associated GATA3 with immunomodulators, cancer immune cycles, tumor-infiltrating immune cells (TIICs), immune checkpoints, and T-cell inflamed scores(TIS). The role of GATA3 in predicting BLCA molecular subtypes and responsiveness to various treatment regimens was also investigated. We confirmed our findings in an external cohort and the Xiangya-Pingkuang cohort to guarantee the correctness of our study. Key Findings GATA3 was preferentially expressed in the TME of numerous malignancies, including BLCA. High GATA3 expression was adversely connected with immunological aspects such as immunomodulators, cancer immune cycles, TIICs, immune checkpoints, and TIS in the BLCA TME. In addition, high GATA3 was more likely to be a luminal subtype, which meant it was less susceptible to cancer immunotherapy and neoadjuvant chemotherapy but more sensitive to targeted treatments. Significance GATA3 may aid in the precision treatment for BLCA because it can accurately predict the clinical outcomes and the TME characteristics of BLCA.

【 授权许可】

CC BY