Impact of Preoperative Type 2 Diabetes Mellitus on the Outcomes of Gastric Cancer Patients Following Gastrectomy: A Propensity Score Matching Analysis

Frontiers in Surgery

article

Yu-Xi Cheng¹  Wei Tao¹  Bing Kang²  Xiao-Yu Liu¹  Chao Yuan¹  Bin Zhang¹  Dong Peng¹ 

[1] Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University;Department of Clinical Nutrition, The First Affiliated Hospital of Chongqing Medical University

关键词: gastric cancer;    type 2 diabetes mellitus;    propensity score matching;    outcome;    prognosis;   

DOI  :  10.3389/fsurg.2022.850265

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose The current study aims to explore the outcomes of type 2 diabetes mellitus (T2DM) on gastric cancer patients following gastrectomy through propensity score matching (PSM) analysis. Methods A retrospective study of gastric cancer patients following gastrectomy was conducted in a single clinical center from January 2014 to December 2019. The short-term outcomes, overall survival (OS) and disease-free survival (DFS) were analyzed between T2DM group and Non-T2DM group. Results A total of 703 patients were enrolled in this study. After 1:1 PSM, 84 patients in T2DM group and 84 patients in Non-T2DM were matched for final analysis. No significant difference was found in terms of operation time, intra-operative blood loss, retrieved lymph nodes, postoperative stay, blood transfusion and complications between T2DM group and Non-T2DM group ( p > 0.05). The Kaplan-Meier curve implied that T2DM had no impact on OS or DFS. Cox regression was conducted to identify predictive factors for prognosis. Body mass index (BMI) ( p = 0.039 < 0.05, HR = 0.725, 95% CI = 0.534–0.983), pre-operative lymphocyte ( p = 0.017 < 0.05, HR = 0.678, 95% CI = 0.493–0.932), pathological tumor node metastasis (pTNM) stage ( p = 0.000 < 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications ( p = 0.006 < 0.05, HR = 1.528, 95% CI = 1.132–2.061) were predictive factors for OS, and BMI ( p = 0.013 < 0.05, HR = 0.524, 95% CI = 0.315–0.872), pTNM stage ( p = 0.000 < 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications ( p = 0.008 < 0.05, HR = 1.892, 95% CI = 1.179–3.036) were independent predictive factors for DFS. Conclusion T2DM did not have an impact on gastric cancer patients following gastrectomy in terms of short-term outcomes and prognosis.

【 授权许可】

CC BY