Frontiers in Surgery | |
Impact of Preoperative Type 2 Diabetes Mellitus on the Outcomes of Gastric Cancer Patients Following Gastrectomy: A Propensity Score Matching Analysis | |
article | |
Yu-Xi Cheng1  Wei Tao1  Bing Kang2  Xiao-Yu Liu1  Chao Yuan1  Bin Zhang1  Dong Peng1  | |
[1] Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University;Department of Clinical Nutrition, The First Affiliated Hospital of Chongqing Medical University | |
关键词: gastric cancer; type 2 diabetes mellitus; propensity score matching; outcome; prognosis; | |
DOI : 10.3389/fsurg.2022.850265 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Purpose The current study aims to explore the outcomes of type 2 diabetes mellitus (T2DM) on gastric cancer patients following gastrectomy through propensity score matching (PSM) analysis. Methods A retrospective study of gastric cancer patients following gastrectomy was conducted in a single clinical center from January 2014 to December 2019. The short-term outcomes, overall survival (OS) and disease-free survival (DFS) were analyzed between T2DM group and Non-T2DM group. Results A total of 703 patients were enrolled in this study. After 1:1 PSM, 84 patients in T2DM group and 84 patients in Non-T2DM were matched for final analysis. No significant difference was found in terms of operation time, intra-operative blood loss, retrieved lymph nodes, postoperative stay, blood transfusion and complications between T2DM group and Non-T2DM group ( p > 0.05). The Kaplan-Meier curve implied that T2DM had no impact on OS or DFS. Cox regression was conducted to identify predictive factors for prognosis. Body mass index (BMI) ( p = 0.039 < 0.05, HR = 0.725, 95% CI = 0.534–0.983), pre-operative lymphocyte ( p = 0.017 < 0.05, HR = 0.678, 95% CI = 0.493–0.932), pathological tumor node metastasis (pTNM) stage ( p = 0.000 < 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications ( p = 0.006 < 0.05, HR = 1.528, 95% CI = 1.132–2.061) were predictive factors for OS, and BMI ( p = 0.013 < 0.05, HR = 0.524, 95% CI = 0.315–0.872), pTNM stage ( p = 0.000 < 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications ( p = 0.008 < 0.05, HR = 1.892, 95% CI = 1.179–3.036) were independent predictive factors for DFS. Conclusion T2DM did not have an impact on gastric cancer patients following gastrectomy in terms of short-term outcomes and prognosis.
【 授权许可】
CC BY
【 预 览 】
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