Long Non-Coding RNA MAFG-AS1 as a Potential Biomarker for Hepatocellular Carcinoma: Linkage with Tumor Features, Markers, Liver Functions, and Survival Profile

Frontiers in Surgery

article

Jiao Wang¹  Ge Tian²  Bing Li³  Moli Chen³  Xiaoning Sun⁴  Yuanyuan Tian³ 

[1] Department of Infectious Diseases, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University;Section of Scientific Research, Beijing Xian Nong Tan Sports Technical College;Department of Gastroenterology, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University;Clinical College, Hainan Medical University

关键词: hepatocellular carcinoma;    lnc-MAFG-AS1;    tumor features;    tumor markers;    prognosis;   

DOI  :  10.3389/fsurg.2022.848831

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose Long non-coding RNAs musculoaponeurotic fibrosarcoma oncogene family, protein G antisense 1 (lnc-MAFG-AS1) regulates hepatocellular carcinoma (HCC) progression and treatment resistance in multiple ways, while its engagement in HCC clinical management remains obscure. The current study aims to explore the relationship of lnc-MAFG-AS1 with tumor features, liver function indexes, tumor markers, and prognosis in HCC patients. Methods One hundred and fifty-two surgical HCC patients who underwent tumor resection were retrospectively analyzed. Their tumor and adjacent tissues were acquired and then proposed to reverse transcription-quantitative polymerase chain reaction to detect lnc-MAFG-AS1 expression. Results Lnc-MAFG-AS1 expression was increased in HCC tumor tissue than in adjacent tissue [median (interquartile range): 2.730 (1.685–4.198) vs. 0.990 (0.703–1.468), p   0.05). In addition, patients with a high expression of lnc-MAFG-AS1 exhibited worse overall survival than those with a low expression of lnc-MAFG-AS1 [median (95% CI): 34.0 (24.5–43.5) vs. 48.0 (41.5–54.5) months] ( p  = 0.011), which was further validated by univariate Cox’s analysis [hazard ratio (HR) = 1.827, p  = 0.013] and multivariate Cox’s analysis (HR = 1.697, p  = 0.040). Conclusion Lnc-MAFG-AS1 relates to multifocal nodules, increased BCLC stage, elevated CNLC stage, and abnormal AFP level and predicts pejorative prognosis in HCC patients.

【 授权许可】

CC BY