Clinical Efficacy of Different Thoracoscopic Surgeries for Patients With Non-small Cell Lung Cancer

Frontiers in Surgery

article

Tao Wang¹  Tao Liang¹  Xiaokuang Ning¹ 

[1] Department of Thoracic Surgery, The First Medical Center of PLA General Hospital

关键词: non-small cell lung cancer;    single-port thoracoscopic surgery;    three-port thoracoscopic surgery;    MMPs-7 mRNA;    sMICA;    T cell subsets;   

DOI  :  10.3389/fsurg.2022.842047

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background The aim of this study was to analyze the clinical efficacy of different thoracoscopic procedures in patients with non-small cell lung cancer and their correlation with matrix metalloproteinase-7 mRNA (MMPs-7 mRNA) and soluble major histocompatibility complex class I molecule A (sMICA), as well as their effect on T-cell subsets. Methods A total of 100 patients with non-small cell lung cancer who received different thoracoscopic surgeries were divided into the Control group (three-port thoracoscopic surgery) and the study group (single-port thoracoscopic surgery). The two groups were evaluated to compare the perioperative indicators, MMPs-7 mRNA, sMICA expression levels, T-cell subsets, postoperative pain, complication rates, and prognostic outcomes at 1-year follow-up. Results The operation time, blood loss, drainage tube placement time, incision length, and hospital stay in the study group were less than those in the control group ( P 0.05). After 3 days, the expression levels of MMPs-7 mRNA and sMICA in the study group were lower than those in the control group ( P 0.05), in which all patients completed the follow-up. After 1 year of follow-up, there was no significant difference in the tumor-free survival rate and overall survival rate between the two groups ( P > 0.05). Conclusion Compared with three-port thoracoscopic surgery, single-port thoracoscopic surgery can improve perioperative expression, shorten hospital stay, reduce serum tumor micrometastasis levels, improve immune metastasis mechanisms and reduce pain, which is of great significance to patients with non-small cell lung cancer. It is an effective, convenient, and safe surgical option that deserves wide clinical reference.

【 授权许可】

CC BY