Factors Associated with Postoperative Lipiduria and Hypoxemia in Patients Undergoing Surgery for Orthopedic Fractures

Frontiers in Surgery

article

Chih-Hui Chen¹  Yun-Che Wu¹  Yu-Cheng Li⁴  Feng-An Tsai⁴  Jen-Ying Li⁴  Jun-Sing Wang²  Cheng-Hung Lee¹ 

[1] Department of Orthopedics, Taichung Veterans General Hospital;Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University;Department of Orthopedic surgery, Changhua Christian Hospital;Department of Pathology & Laboratory Medicine, Taichung Veterans General Hospital;Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital;Ph.D. Program in Translational Medicine, National Chung Hsing University;Department of Food Science and Technology, Hung Kuang University

关键词: fracture;    hypoxemia;    lipiduria;    orthopedics;    surgery;   

DOI  :  10.3389/fsurg.2022.814229

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

We investigated factors associated with postoperative lipiduria and hypoxemia in patients undergoing surgery for orthopedic fractures. We enrolled patients who presented to our emergency department due to traumatic fractures between 2016 and 2017. We collected urine samples within 24 h after the patients had undergone surgery to determine the presence of lipiduria. Hypoxemia was defined as an SpO 2 <95% determined with a pulse oximeter during the hospitalization. Patients’ anthropometric data, medical history, and laboratory test results were collected from the electronic medical record. Logistic regression analyses were used to determine the associations of clinical factors with postoperative lipiduria and hypoxemia with multivariate adjustments. A total of 144 patients were analyzed (mean age 51.3 ± 22.9 years, male 50.7%). Diabetes (odd ratio 3.684, 95% CI, 1.256–10.810, p  = 0.018) and operation time (odd ratio 1.005, 95% CI, 1.000–1.009, p  = 0.029) were independently associated with postoperative lipiduria, while age (odd ratio 1.034, 95% CI, 1.003–1.066, p  = 0.029), body mass index (odd ratio 1.100, 95% CI, 1.007–1.203, p  = 0.035), and operation time (odd ratio 1.005, 95% CI, 1.000–1.010, p  = 0.033) were independently associated with postoperative hypoxemia. We identified several factors independently associated with postoperative lipiduria and hypoxemia in patients with fracture undergoing surgical intervention. Operation time was associated with both postoperative lipiduria and hypoxemia, and we recommend that patients with prolonged operation for fractures should be carefully monitored for clinical signs related to fat embolism syndrome.

【 授权许可】

CC BY