Asymmetric Dimethylarginine: Relationship with Circulating Biomarkers of Inflammation and Cardiovascular Disease Risk in Uncomplicated Obese Women

European Journal of Inflammation

Original Article

P. Magni¹  E. Dozio²  E. Galliera²  G. Dogliotti²  U. Solimene³  M.M. Corsi⁴  E. Costa⁵  A.E. Malavazos⁶  L. Morricone⁶  S. Goggi⁶ 

[1]Department of Endocrinology, Physiopathology and Applied Biology, University of Milan, Milan

[2]Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, Milan

[3]Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, Milan

[4] Center for Research in Medical Bioclimatology, University of Milan, Milan

[5]Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, Milan

[6] Operative Unit of Clinical Pathology Laboratory, Department of Health Services of Diagnosis and Treatment - Laboratory Medicine, IRCCS Policlinico San Donato, Milan, Italy

[7]Operative Unit of Clinical Pathology Laboratory, Department of Health Services of Diagnosis and Treatment - Laboratory Medicine, IRCCS Policlinico San Donato, Milan, Italy

[8]Operative Unit of Diabetology and Metabolic Diseases, IRCCS Policlinico San Donato, Milan

关键词: asymmetric dimethylarginine;    cardiovascular risk;    obesity;    inflammation;   

DOI  :  10.1177/1721727X1100900305

 received in 2011-03-31, accepted in 2011-07-01,  发布年份 2011

来源: Sage Journals

【 摘 要 】

In recent years, the link between obesity, inflammation and atherosclerosis has attracted increasing interest. Recently, besides the classical inflammatory markers, the competitive nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA) has been shown to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Since obese people present a condition of chronic low-grade inflammation and endothelial dysfunction, in the present study we quantified ADMA levels in uncomplicated obese women (with no clinical, cardiac or metabolic complications) and normal-weight control subjects. We investigated the relationship of ADMA with some anthropometric measurements, abdominal visceral and subcutaneous adipose tissue accumulation, and biochemical and proinflammatory factors of the subjects [interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL6-R/IL-6 ratio, tumor necrosis factor alpha (TNFα), homocysteine (Hey) and plasminogen activator inhibitor-1 (PAI-1)]. ADMA and all the other pro-inflammatory parameters resulted higher in obese patients than in healthy subjects. ADMA significantly correlated with Hey, PAI-1, TNFα and with sIL-6R/IL-6 ratio but not with other anthropometric and biochemical parameters. In a stepwise regression analysis ADMA correlated most closely with Hey and TNFα. In conclusion, in our obese uncomplicated patients TNFα and Hey emerged as strong predictors of ADMA which might be a potential mediator of the effects of different risk factors affecting the cardiovascular system.

【 授权许可】

Unknown   
© 2011 SAGE Publications