Inflammatory Markers: Serum Amyloid A, Fibrinogen and C-Reactive Protein — A Revisited Study

European Journal of Inflammation

Editorial

A. Saggini¹  Y.B. Shaik-Dasthagirisaheb²  G. Maccauro³  P. Conti⁴  V. Salini⁵  A. Caraffa⁶ 

[1] Department of Dermatology, University of Rome Tor Vergata, Rome, Italy;Department of Medicine, Boston University School of Medicine, Boston, MA, USA;Department of Orthopaedics, Catholic University of Rome, Rome, Italy;Immunology Division, University of Chieti-Pescara, Medical School, Chieti, Italy;Orthopaedic Division University of Chieti-Pescara, Medical School, Chieti, Italy;Orthopaedics Division, University of Perugia, Perugia, Italy;

关键词: acute phase proteins;    innate defence;    amyloid A;    fibrinogen;    C-reactive protein;    cytokines;   

DOI  :  10.1177/1721727X1100900202

 received in 2011-03-23, accepted in 2011-06-14,  发布年份 2011

来源: Sage Journals

【 摘 要 】

The acute phase response is the part of the innate defence system of an animal against trauma, inflammation or infection. During this response, there is increased production and release of certain plasma proteins known as acute phase proteins, which include C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen (Fg). CRP consists of five identical subunits of 206 amino acids with a molecular weight of approximately 23 kDa. There is strong evidence from numerous studies that CRP is a predictor of inflammation. The acute-phase protein serum amyloid A (SAA) is a clinically useful marker of inflammation. SAA plays not only an important role in the development of AA amyloidosis (an important complication of rheumatoid arthritis) but also interacts with events closely involved in the metabolic syndrome as a high- and low-grade inflammatory modulator. Fibrinogen (Fg) is a high molecular weight plasma adhesion protein and is a biomarker of inflammation. It is synthesized and assembled in hepatocytes and fibroblasts and when secreted into the circulation, its plasma half-life ranges from 3 to 4 days. Several cytokines, are involved in the induction of acute phase protein synthesis, but the mutual importance of these cytokines seems to be cell-type specific and to vary in various experimental settings. Here we revisited the classic acute phase proteins SAA, C-Reactive protein and fibrinogen in their role in inflammation and their interrelationship with some cytokines.

【 授权许可】

Unknown   
© 2011 SAGE Publications